Amlodipine Therapy for Iron-Overload Cardiomyopathy: The Enduring Value of Translational Research.
نویسندگان
چکیده
Editorial Amlodipine Therapy for Iron-Overload Cardiomyopathy: The Enduring Value of Translational Research Gavin Y. Oudit, MD, PhD, FRCPC, and Peter H. Backx, DVM, PhD Division of Cardiology, Department of Medicine, Edmonton, Alberta, Canada Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada Division of Cardiology, Peter Munk Heart Centre, University Health Network, Toronto, Ontario, Canada Department of Physiology, University of Toronto, Toronto, Ontario, Canada
منابع مشابه
Effect of L-type calcium channel blocker (amlodipine) on myocardial iron deposition in patients with thalassaemia with moderate-to-severe myocardial iron deposition: protocol for a randomised, controlled trial
INTRODUCTION Sideroblastic cardiomyopathy secondary to repeated blood transfusions is a feared complication in thalassaemia. Control of myocardial iron is thus becoming the cornerstone of thalassaemia management. Recent evidence suggests a role for L-type Ca(2+) channels in mediating iron uptake by the heart. Blocking the cellular iron uptake through these channels may add to the benefit of the...
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Advances in the management of transfusion dependent thalassemic patients have improved the survival of these patients. The most important consequence of repeated and frequent transfusions is iron accumulation in vital organs. The magnetic resonance imaging (MRI) is a non-invasive and valid technique for the estimation of iron stores. Despite multiple studies about cardiac and liver MRI T2*, the...
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Regular packed cell transfusion in patients with thalassemia major leads to iron overload. Chelation therapy is one of the important aspects of thalassemia care as iron overload causes significant cardiac, hepatic, and endocrine dysfunction. We report a case of thalassemia major with severe iron overload causing cardiac and liver dysfunction who benefitted from triple drug chelation therapy. Tr...
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ورودعنوان ژورنال:
- The Canadian journal of cardiology
دوره 32 8 شماره
صفحات -
تاریخ انتشار 2016